5 Best Weed Strains to Help with Depression

Are you looking for the best cannabis strains to help with depression? Here’s a quick review of some of the best Indica, Hybrid, and Sativa strains that help you relieve depression.

We’ll break it down with strains like Tropic Truffle and Blueberry Mac, keeping it super simple so you can figure out what to smoke and what might help you feel better.

Overview of the Best Strains for Depression

Overview of the Best Strains for Depression

It can be hard to figure out which marijuana strains are ideal for you, especially if you are looking for help with depression symptoms.

We’ve made it easy for you by listing some strains that might do the trick. Check them out:

Tropic Truffle

Tropic Truffle is a Sativa-dominant strain that’s a cross between Tropicana Cookies and Mint Chocolate Chip.

This is a strong strain, with 21% THC level, which helps shake off stress and tiredness. The buds are lime green with a touch of purple, a signature look from its creators, Exotic Genetix.

It’s known for giving you a joyful mood and is perfect for socializing.

Tropic Truffle
Tropic Truffle Bud

Price: 65$/7g

What we like:

  • Refreshing flavor.
  • Increases energy.
  • Stimulates creativity.

What we don’t like:

  • Causes dry, irritated eyes.
  • Not effective for severe pain relief.
  • Short-lasting high.

Tropic Truffle strain reviews

  1. “Tropic Truffle is one of my go-to cannabis strains for depression relief. It smells like fresh citrus and lifts your mood right away. It’s great for staying active and helps with my headaches and anxiety. Gives you a nice little boost without slowing you down!” – KikiBunny39
  2. “This was my first time trying a Hybrid cannabis strain after only using Indica and Sativa strains for years. I usually tread carefully with my mental health issues, but this strain was great. I took a few hits over an hour and got a happy, giggly high without any sleepiness.” – Dazzling-Finger7576

Sugar Kush

Sugar Kush is an Indica-dominant cross between Kandy Kush and Hash Plant. It’s got a THC level of 14%, making it a solid choice if you’re looking to relax.

This strain has a citrusy smell thanks to its main terpene, limonene, which is great for relieving stress. Sugar Kush also has pinene, and caryophyllene, which adds a hint of spice.

It’s great for depression, anxiety, insomnia, and boosting your mood.

Sugar Kush Weed Bud
Sugar Kush Bud

Price: 60$/7g

What we like:

  • Helps with chronic pain.
  • Relieves anxiety.
  • Manages stress.

What we don’t like:

  • Not suitable for vaporizers due to high oiliness.
  • Hard to roll.
  • Strong aroma.

Sugar Kush strain reviews

  1. “Sugar Kush is a great pick to lighten up and relax. It’s smooth to smoke and has a mild taste. Perfect for an evening session, it got us laughing a bunch and then eased us into a calm state, ready for sleep. It’s one of my go-to strains. I highly recommend it!” – enonymous617
  2. A solid choice if you’re dealing with depression symptoms and chronic pain. It offers a relaxing body high without too much of a head buzz. The effects kick in slowly and keep you chill, perfect for a relaxed night. It’s not the strongest strain, but it does the job well, helping you unwind without knocking you out immediately. Great for smoking throughout the evening to ease your mood and relax.” – SomkeyNY1983

Space Cake

Space Cake is a Hybrid strain with a THC level of 22%, perfect for when you want to kick back and boost your mood.

It’s a mix of GSC Forum Cut Cookies and Snow Lotus, giving it a creamy berry flavor.

If you’re looking to ease your mind without too much fuss, Space Cake might be your new favorite.

Space Cake Strain

Price: 60$/7g

What we like:

  • Smooth smoke.
  • Long-lasting effects.
  • Perfect for social gatherings.

What we don’t like:

  • Mental fog.
  • Energy crash.
  • May cause dizziness.

Space Cake strain reviews

  1. “Space Cake is awesome for lifting your mood and managing depression. It’s strong but not overwhelming, and it helps lighten up those tough days. It’s smooth, tastes great, and makes you feel relaxed without being too heavy. A go-to when you need a cheerful boost to fight depression.” – AccomplishedSuit1004
  2. “Space Cake stands out! It’s got a bright fluorescent green look when ground up, but watch out, it’s super strong. Great for knocking out aches and pains, and it’s one of my top 5 strains. Just a heads-up, though—it can leave you with a bit of mental fog and an energy dip after it wears off. Overall, it’s pretty impressive.” – theycmeroll

Gorilla Grapes

Gorilla Grapes is a Hybrid strain with 17% THC. It’s a blend of Original Glue and Vino OG, offering a sweet grape taste with diesel undertones.

The buds are olive with purple and red highlights, coated in sticky trichomes. Great for anyone needing a mood boost.

Gorilla Grapes Bud

Price: 35$/7g

What we like:

  • Offers a balanced high.
  • Lower risk of paranoia.
  • Enhances outdoor activities.

What we don’t like:

  • Couch Lock.
  • Sticky buds.
  • Induces sleepiness.

Gorilla Grapes strain reviews

  • “Gorilla Grapes stands out if you’re looking to ease depression. It hooks you immediately with its strong diesel and grape smell. The blend of terpenes gives you a nice mental clarity while keeping your body relaxed. It’s great for when you want to calm your mind and still feel chilled out.” – Spacecommander5
  • This strain helps with depression by relaxing your body while keeping your head clear. You can move around if needed, but it’s so relaxing you might not want to. The only minor downside is a dry mouth.” – Acceptable_News9801

Blueberry Mac

Blueberry Mac is an Indica-dominant Hybrid marijuana strain that combines Blueberry Zkittlez and MAC. With a THC level of 26%, it’s great for those who need a chill-out.

The buds have green and purple hues and trichomes with orange hairs. It tastes as good as it smells, offering sweet berry flavors with earthy and creamy undertones.

Blueberry Mac is your strain if you want something to help you relax and feel happier.


Price: 65$/7g

What we like:

  • Rich in terpenes.
  • Good for evening use.
  • Body buzz.

What we don’t like:

  • Increased munchies.
  • Dry mouth and eyes.
  • May cause migraines.

Blueberry Mac strain reviews

  1. “Blueberry Mac is a classic strain if you’re looking to treat depression or physical pain. It easily gets a five-star rating from me. This strain will sneak up on you, suddenly making you feel hungry and relaxed. It’s strong, so it might not be for everyone, but I highly recommend trying it if you find it. It’s great for chilling out and lifting your spirits.” – tundybundo
  2. Great pick for fighting depression and mood disorders. It has a nice, fruity, and strong smell that lifts your spirits just from the aroma. It’s also good for easing pain and boosting your appetite. The smell excites you for what’s to come, and the effects deliver, leaving you feeling uplifted and satisfied.” – Weird-Treat8741

Choosing the Right Strain for You

When looking for the best weed strain for depression, you need to think about whether you like Indica, Sativa, or Hybrid strains, as well as how much THC and CBD they contain.

Indica strains generally help with relaxation and are great if you’re dealing with mental health issues like anxiety and depression.

Sativa strains can give you an energy boost if you’re feeling down, while Hybrid strains offer a mix of both.

It’s also interesting to try other ways of getting high, like vaping or eating edibles (marijuana infused food), especially if you’re not into smoking.


Cannabis offers a promising way to manage depression with different strains like Tropic Truffle, Sugar Kush, Space Cake, Gorilla Grapes, and Blueberry Mac, each providing its own benefits.

Whether you need to relax, energize, or inspire creativity, there’s likely a marijuana strain that fits your needs.

Frequently Asked Questions

How can I tell if a strain is too strong for me?

If you feel overwhelmed or too anxious after smoking, it might be too strong for you. Start with small amounts to see how you react.

Do these marijuana strains smell strong?

Yes, most strains, like Gorilla Grapes and Blueberry Mac, smell strong, especially when you open the container.

How often should I use these strains for depression?

It depends on how you feel, but it’s important not to overdo it. Start small and see what works for you.

What does Blueberry Mac taste like?

Blueberry Mac tastes like berries with a hint of earthy flavor. It’s pretty sweet and enjoyable if you like fruity strains.

Can Gorilla Grapes help with sleep?

Yes, Gorilla Grapes can help you relax and might make it easier to fall asleep.

I’m Zoey Roy, a Cannabis Compliance Specialist and Cannabis Activist. I am experienced in guiding individuals and businesses through complex cannabis regulations. With a Bachelor’s degree in Research from McGill University, I’ve worked at Neptune Wellness for 4 years as a senior researcher. Now I serve as a Cannabis Industry Analyst at Tilray Brands, Inc. I provide essential support in ensuring compliance, educating clients, and facilitating legal requirements. My expertise extends to marketing and laboratory skills, making me a well-rounded professional in the field.

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