Is CBD Toxic to the Liver? (Evidence from Latest Studies)

No, Normal doses of CBD do not induce liver toxicity. Overuse of CBD causes liver toxicity. Studies have indicated that both CBD oil and cannabidiol extracts sold online may lead to elevated liver enzymes and adverse events.

But, high doses of CBD use may cause adverse effects like liver toxicity, reproductive and developmental impacts, and drug interactions.

More human studies are needed to fully understand the effects of CBD on liver function. Keep reading.

How Can CBD Affect Liver Health?

CBD may impact liver health by potentially elevating liver enzymes, indicative of possible liver damage. It occurs primarily with very high doses of CBD or when combined with specific medications.

According to “The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease by Aleksandra Kicman,” CBD doesn’t harm other vital organs, such as the kidneys or the heart.

While CBD is generally well-tolerated, individuals using high doses or taking it alongside certain medications should exercise caution.

Five Factors Influencing CBD’s Impact on the Liver

Five Factors Influencing CBD's Impact on the Liver

There are five factors influencing CBD’s impact on the liver are given below:

1. Dosage Levels

Both CBD oil and other cannabidiol extracts sold online come in various concentrations. Studies suggest that higher doses of CBD may lead to adverse events, including potential liver injury. Understanding the appropriate dosage is crucial to avoid elevated liver enzymes and adverse effects.

2. Interaction with Medications

CBD has the potential to interact with prescription medications. For individuals taking other drugs, especially those processed by the liver, exercise caution. Drug interactions could impact liver function, leading to elevated liver enzymes and other adverse events.

3. Preexisting Liver Conditions

Individuals with preexisting liver conditions may face increased risk. Those with impaired liver function or chronic liver diseases should be vigilant when considering CBD products. Consulting with primary care providers is essential, especially for those with a history of liver enzyme elevations.

4. Quality of CBD Products

Contaminants in low-quality products may contribute to liver toxicity. Choosing reputable sources and products is imperative, ensuring they meet health standards and regulations.

5. Mode of Administration

The method of CBD consumption matters. Oral cannabidiol, such as CBD oil, undergoes processing by the liver, potentially influencing its impact. Understanding how different modes of administration affect the liver is essential for managing potential risks.

Research on CBD and Liver Health

Some studies suggest that high doses of CBD could potentially lead to adverse effects on the liver. According to “LiverTox: Clinical and Research Information on Drug-Induced Liver Injury by Bethesda,” While CBD is generally considered safe, there have been instances of elevated liver enzymes and drug-induced liver injury associated with its use.

Much of this evidence comes from preclinical studies, and further research is needed to fully understand the relationship between CBD and liver toxicity in humans. The World Health Organization has acknowledged that CBD is generally well-tolerated in healthy adults.

However, caution is advised, especially for individuals with impaired kidney function or chronic kidney disease. Additionally, factors such as drug interactions, elevated liver enzymes, and increased risk in individuals with severe renal impairment must be considered.

Safety and Recommendations

Safety and Recommendations

CBD oil is administered by placing it under your tongue for rapid absorption into the bloodstream. Research suggests that CBD is generally safe when taken orally in small doses over a short period. Studies indicate that up to 200 milligrams daily for 13 weeks poses minimal risk.

While CBD has shown promise in areas like pain management, further research is needed to understand its effects fully. Monitor product quality, as some cannabidiol extracts sold online may contain toxic contaminants.


Does CBD Lead to Heart Problems?

No evidence suggests that CBD leads to heart problems. Numerous studies have explored the safety of cannabidiol (CBD) in various contexts, including its impact on the cardiovascular system. Research indicates that CBD does not adversely affect blood pressure or blood flow. While the discussion on CBD and its potential health benefits continues, there is currently no substantial evidence linking CBD use to adverse events related to heart health.

Is CBD Oil Hard on the Kidneys?

No, CBD oil is not hard on the kidneys. Research suggests that CBD, derived from the cannabis plant, does not adversely affect kidney function. Studies have explored its potential benefits for various medical conditions, including chronic pain and symptom management.

Does CBD Oil Affect Creatinine Levels?

CBD oil supplementation has a potential impact on creatinine levels. According to “Evaluation of an Oral Supplemental Cannabidiol Product for Acceptability and Performance in Mature Horses by Julia M. Leise,” Creatinine levels tended to decrease with increasing CBD supplementation. Creatinine is a byproduct of muscle activity, where creatine is used for energy production.

Final Thoughts: CBD & Liver Health

Initial research suggests that CBD poses minimal risk of adverse effects on the liver. The evidence suggests minimal adverse effects, with potential harm only arising from excessively high doses.

According to “Cannabinoids and Chronic Liver Diseases by Ralph-Sydney Mboumba Bouassa,” CBD is not a known contributor to liver failure, a severe condition associated with factors like obesity, alcohol misuse, and hepatitis.

CBD lacks the characteristics linked to hepatic issues. As with any substance, moderation is vital, and caution should be exercised, especially in cases of self-medication or when combining CBD with other medications.


  • Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice (April 7, 2011) Y Avraham, NC Grigoriadis, T Poutahidis, L Vorobiev, I Magen,1 Y Ilan, R Mechoulam, and EM Berry
  • The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence (January 1, 2023) Jonathon C. Arnold, Danielle McCartney, Anastasia Suraev, Iain S. McGregor
  • An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies (June 1, 2017) Kerstin Iffland, and Franjo Grotenhermen
  • Observed Impact of Long-Term Consumption of Oral Cannabidiol on Liver Function in Healthy Adults (December 16, 2021) Robert Kaufmann, Keith Aqua, Jeff Lombardo, Martin Lee
  • Therapeutic Efficacy of Cannabidiol (CBD): A Review of the Evidence from Clinical Trials and Human Laboratory Studies (September 3, 2020) Dennis J Sholler, Lauren Schoene, Tory R Spindle

I’m Zoey Roy, a Cannabis Compliance Specialist and Cannabis Activist. I am experienced in guiding individuals and businesses through complex cannabis regulations. With a Bachelor’s degree in Research from McGill University, I’ve worked at Neptune Wellness for 4 years as a senior researcher. Now I serve as a Cannabis Industry Analyst at Tilray Brands, Inc. I provide essential support in ensuring compliance, educating clients, and facilitating legal requirements. My expertise extends to marketing and laboratory skills, making me a well-rounded professional in the field.

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